Lance Reddickas Lt. Cedric Daniels
Sonja Sohnas Det. Shakima "Kima" Greggs
Dominic Westas Off. James "Jimmy" McNulty
Clarke Petersas Det. Lester Freamon
Domenick Lombardozzias Det. Thomas "Herc" Hauk
Wendell Pierceas Det. William "Bunk" Moreland
Seth Gilliamas Det. Ellis Carver
Jim True-Frostas Det. Roland "Prez" Pryzbylewski
John Domanas Dep. Comm. William A. Rawls
Deirdre Lovejoyas Assistant State's Attorney Rhonda Pearlman
Michael K. Williamsas Omar Little
Andre Royoas Reginald "Bubbles" Cousins
Idris Elbaas Russell "Stringer" Bell
Frankie Faisonas Ervin Burrell
Aidan Gillenas Councilman Thomas "Tommy" Carcetti
J.D. Williamsas Preston "Bodie" Broadus
Wood Harrisas Avon Barksdale
Jamie Hectoras Marlo "Black" Stanfield
Corey Parker Robinsonas Det. Leander Sydnor
Gbenga Akinnagbeas Chris Partlow
Robert Wisdomas Maj. Howard "Bunny" Colvin
Isiah Whitlock Jr.as State Sen. R. Clayton "Clay" Davis
Reg E. Catheyas Norman Wilson
Michael Kostroffas Maurice "Maury" Levy
Jermaine Crawfordas Duquan "Dukie" Weems
Chad L. Colemanas Dennis "Cutty" Wise
Amy Ryanas Off. Beatrice "Beadie" Russell
Lawrence Gilliard Jr.as D'Angelo Barksdale
Glynn Turmanas Mayor Clarence V. Royce
Paul Ben-Victoras Spiros "Vondas" Vondopoulos
Mack Wildsas Michael Lee
Chris Baueras Frank Sobotka
Neal Huffas Chief of Staff Michael Steintorf
Michelle Paressas Alma Gutierrez
Clark Johnsonas City Editor Augustus "Gus" Haynes
Thomas McCarthyas Scott Templeton
